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Nation's first Center for Environmental Genetics houses historic Fernald samples

Tucked away in Clifton on the medical side of UC's campus, researchers at the nation’s first Center for Environmental Genetics continue groundbreaking work, but with a new twist.

Their latest research game-changer involves decades worth of carefully documented biological samples now available for use by their peers all over the world.

If you have never heard of the Center for Environmental Genetics, you are not alone. Housed within the largest department of UC’s College of Medicine, the Department of Environmental Health, the CEG funds research on genetic (your personal script, already written at birth) and epigenetic (beyond genetics – how what you are exposed to today may impact your children’s genes and even further down the line) levels.

Conducting epigenetic studies can be particularly challenging, since multiple generations and variations of exposures are involved. That’s where a long-term human cohort study, started years ago as part of a $78 million settlement at the Fernald Feed Materials Processing Center, comes into play.

For years, residents around the Fernald plant had no idea that their neighbor was manufacturing uranium, not livestock feed. The long-term drama that ensued as the plant was shut down became the stuff of class action lawsuit history. What many residents wanted as much as restitution for their poisoned property was medical help and advice about how their homes might have made them, and their children, and their children’s children, sick.

So the settlement included an important stipulation: the largest medical monitoring project of its kind. From 1990 until 2008, residents were monitored and samples collected from all ages and all backgrounds. The cohort included multi-generational families, with sample collections coded to reflect their relationships.

At the end of the monitoring period, 160,000 biological samples from more than 9,500 participants are now stored at UC’s CEG. Not only can they be used to help examine and improve the lives of the participants and their families, but they can also be sent to researchers around the world who need stable, high-quality samples for their own genetic and epigenetic research.

Locally, doctors found evidence of increased cancer risk among residents, but they also were able to suggest opportunities that might help lower residents’ other risk factors, including the incidence of diabetes and heart disease.

As researchers and community members gathered on UC’s campus last month to discuss the decades-long project, participants and researchers agreed that, when done correctly and comprehensively, medical monitoring leads to both better health and better research.

Source: University of Cincinnati
Writer: Elissa Yancey

This story originally appeared in sister publication Soapbox.

NanoLogix growth fuels move to new R&D lab

The closing of a business incubator in Cincinnati has prompted NanoLogix, the Hubbard-based firm specializing in early detection of harmful microorganisms, to move its main R&D laboratory.

Instead of the Queen City, the lab will now be housed in the company's 4,000-square-foot headquarters building in Hubbard.

"It was an unanticipated move, but one that ultimately we're happy with," says Bret Barnhizer, NanoLogix's CEO.

For the past five years, NanoLogix's research and development was being done at the BioStart incubator in Cincinnati by a team of scientists. The company had even planned to expand that team, adding a two more scientists. That changed abruptly earlier this summer, when the site announced it would close by Sept. 30.  

According to Barnhizer, it didn't take long to come to the conclusion that consolidation was in the company's best interest.

"We looked around and there wasn't a deal with incentives like we had with BioStart. We had a phenomenal deal that gave us access to equipment and facilities we couldn't find elsewhere. But, we had this extra space in Hubbard. We happened to have just completed a clean-room production facility. And, if you needed to talk to one of our scientists, all you would have to do is walk down the hall," he says. "It turned out to be a wonderful move for us."

Now, all NanoLogix activities, from R&D to production and management, will be under one roof. The move comes at a time when the firm continues to validate their work on early detection of bacteria and other harmful microorganisms, including a 300-patient clinical trial being conducted at the University of Texas Health Science Center in Houston and work on new a new product line that could lead to early detection of tuberculosis.

According to Barnhizer, the work will continue seamlessly.

"We'll be scaling down our operations in Cincinnati about the same time we start working in Hubbard," he explains. "The move will help us save thousands of dollars per month in rent we won't have to pay, not to mention the efficiency savings involved."

With most of their lab staff opting to remain in Cincinnati, NanoLogix will also be hiring new scientists to man the new lab. The staff additions planned for Cincinnati will bring additional staff to the Hubbard site, he says.

"I won't denigrate the work our people in Cincinnati did for us, but this is a natural move. We're excited about the opportunities it affords us as we move forward," says Barnhizer.

Source: Bret T. Barnhizer, NanoLogix
Writer: Dave Malaska

PEDCO's journey a lesson in changing worker demographics, industry needs

For most of its history, Sharonville-based PEDCO  was content to be the "quiet company" among full-service engineering and architectural consulting firms.

No longer. Renewed attention to its future, development of a strategic plan and a new emphasis on cross-disciplinary, cross-generational interaction has led to growth in a sluggish industry, says Bill Giesler, PEDCO's president.

The company, which celebrated its 30th birthday in August, enjoyed revenue growth of 20 percent last year, is on track for more of the same in 2011, and is hiring.

"We're bucking the trend," Giesler says.

He says the catalyst for the company's renewed energy came seven years ago.

"2004 was a lousy year," he explains. "It made us look internally at who are we, what do we want to be?"

With the help of a national consultant, began laying the groundwork in 2006. One result was an increased reliance on technically trained people in business development, Giesler says.

"Engineers and architects have no formal training in business development and marketing," he explains. The company needed an approach whereby technical people understood how to leverage relationships to build more business, he explains.

Developing a strategic plan was a key to the company's turnaround, Giesler says. In 2006 and 2007, PEDCO formulated its first roadmap, one that was renewed earlier this year. While the first plan relied on the input of senior management, the second plan included a cross-functional array of PEDCO employees and a representative from every functional area.

As the company noticed results, more attention was placed on attracting and advancing younger employees -- a critical task at a time when the number of engineering grads going into the consulting field was dropping, says Jerry Doerger, VP operations.

"Millennials want flexibility, time to be with their families. We started to recognize that. Also, Millennials were multi-taskers, sometimes working with an iPod in their ears. We needed to be able to allow multi-tasking and understand and accept Millennials for what they were."

Existing employees, too, expressed a desire to know more about how the business was run and how to contribute to its success, he says. Today, every new employee is assigned a mentor to school them in the "PEDCO Way." It's not only an opportunity to learn, but "it's an avenue for feedback and ideas."

PEDCO employees 84, mostly in Ohio (the company also has an office in Fort Wayne, Ind.), with 18 hired since October. Giesler says the company is currently looking to fill an additional seven or eight positions.

Sources: Bill Giesler and Jerry Doerger, PEDCO
Writer: Gene Monteith

Entrepreneurship programs at three Ohio universities ranked among top 25 in the nation

The next generation of Ohio entrepreneurs is in good hands, according to a prestigious ranking of college and university entrepreneurship programs.

The Princeton Review and Entrepreneur Magazine surveyed more than 2,000 entrepreneurship programs, and ranked three Ohio universities among the top 25 undergraduate programs in the U.S. The University of Dayton's Entrepreneurial Leadership Program is ranked no. 12, followed by Miami University's Institute for Entrepreneurial Leadership at no. 15, and Xavier University's Sedler Family Center for Entrepreneurship and Innovation at 25.

The survey covered the 2010-2011 academic year, and ranked schools based on features inside and outside of the classroom. That included academics and requirements, percentage of students enrolled in entrepreneurship programs, and percentage of graduates and faculty had run, started or bought a successful business. The survey also looked at schools' partnerships with other institutions to allow access to the entrepreneurship program, and budgets for clubs and organizations that support entrepreneurship.

The results put the universities in the company of number one-ranked University of Houston, as well as Baylor University, Syracuse University and Brigham Young University.

At the three universities, there are a total of 865 students enrolled in entrepreneurship programs, who have access to 21 entrepreneurship organizations and clubs and 14 mentor programs.

Sources: Debora Del Valle, Director for Public Relations Xavier University; and University of Dayton communications
Writer: Feoshia Henderson

Cincinnati Innovates highlights 12 southwest Ohio innovators

While chores may never make it to your child's bucket list, two Cincinnati entrepreneurs are developing a web-based and mobile application that can make them more enjoyable.

The idea was enough to garner Chris Bergman and Paul Armstrong's ChoreMonster a $25,000 CincyTech Commercialization award at this year's Cincinnati Innovates competition.

ChoreMonster, now under development, connects chores and rewards through a point system. The application, which can be accessed by parents and their children, awards kids points based on the type of chore they complete. The points can then be cashed in for real rewards like a gaming system or a night out at the movies.

ChoreMonster was among a dozen local entrepreneurs recently shared $115,000 in grants awarded by Cincinnati Innovates, a nonprofit in search of the "next big thing. Cincinnati startup Acceptd, which is developing web-based software designed to make it easier for university professionals to manage video applications for creative and sports programs, also won a $25,000 commercialization award.

"For the most part we're looking for entrepreneurs with a 'disruptive' innovation, with the potential to grow into great companies," says Elizabeth Edwards, founder of Metro Innovation and organizer of the competition. "These disruptive innovations have the potential to completely transform a marketplace."

In the past three years, more than 1,000 local entrepreneurs have participated in the annual competition, and winners have divvied up a total of $250,000 in grants provided by 23 sponsors. Past winners have raised over $3.5 million in follow-on capital, have been featured in national media, and are changing the world with their ideas.

This year's dozen innovators will save stroke victims, help travelers avoid missing flights, protect firefighters, stimulate kids to do their chores, and help to draft better fantasy sports teams.

"Cincinnati Innovates was a joint effort between CincyTech, the Taft law firm, Soapbox  and myself," says Edwards. "The awards are important in helping to identify aspiring entrepreneurs. Typically, aspiring entrepreneurs don't wear tee shirts that say, 'I'm thinking about starting a company.'"

She adds: "We are looking at things at the concept stage, before a business plan is even written . . . entrepreneurs must have a nearly transformational innovation and be serious about commercializing it. CincyTech, for example, has three awards . . . they're typically looking for healthcare and IT companies, something that offers a potential market exceeding 250 million dollars," says Edwards.

Other awards are outside the healthcare and IT markets.
 
Sources: Elizabeth A. Edwards, Metro Innovation; Soapbox
Writer: Patrick G. Mahoney

UC's FETCH-LAB research helps pets, people

The idea of putting hearing aids on a dog may, to the uninitiated, seem like an extravagant splurge, the kind of move reserved for those with money to burn. But not to a team of researchers at the University of Cincinnati. It's one of several innovative projects designed to better understand how animals hear and communicate, with the hope of making the world more comfortable for both humans and our animal counterparts.

"This research has been going on for some time," says Pete Scheifele, PhD, head of UC's Facility for the Education and Testing of Canine Hearing and Lab Animal Bioacoustics (FETCH-LAB). "However, the noise impacts on animals have not been on the forefront, especially on animals that are domestic or captive."

Scheifele explains that, for years, vets and animal researchers paid little attention to hearing loss in animals such as domestic dogs. Owners who brought in their pets with concerns over hearing loss often saw vets use primitive tests, such as jingling keys or snapping and looking for reactions. When researchers started using pediatric hearing-test equipment to study dogs, however, an alarming trend surfaced: About 60 dog breeds showed a tendency toward congenital deafness, due in part to inbreeding.

"The awareness kind of shot up, because everyone's worried about having a deaf dog," he says. "It's had a domino effect."

Now, vets and researchers are working to identify causes of animal deafness, especially in service animals such as police and rescue dogs.

"Your job, perhaps your life, may depend on your working partner," Scheifele says.

FETCH-LAB scientists have also explored ways to combat excessive noise in places supposed to meet physical and mental needs. Kennels, for example, often have highly reflective walls and ceilings that bounce barks and yips into an annoying - and potentially harmful - cacophony.

"Kennels are made to be washed, not for hearing safety," he says.

The FETCH-LAB team recently installed sound-dampening panels at the League for Animal Welfare's kennel in Batavia, and is studying their effects on the sound levels and the health of both canine inhabitants and employees. And although Scheifele says testing is still underway, LFAW Director Mary Sue Bahr says that the panels are having a significant effect.

"Our goal for all of the dogs in our care is to provide a clean, healthy, friendly, stress-free environment for them,” says Bahr in a UC press release. "Having these sound panels helps us to fulfill that goal—and it’s also nice for our staff and volunteers. In reducing the sound levels, it helps them have a more enjoyable time here.”

Scieifele says FETCH-LAB also studies hearing and hearing loss in horses and marine animals, and is in the process of publishing a paper on optimizing aquarium design to provide stimulating - but not overwhelming - amounts of noise for captive inhabitants. The work, he explains, could both improve lives for animals, and could effect the way human hearing and noise control takes shape in the future.

"We often come back with information that's useful and say, 'we never thought about this in humans,'" he says. "We help the animals, and they help us."

Source: Pete Scheifele, University of Cincinnati
Writer: Matt Cunningham

This story originally appeared in sister publication Soapbox.

Ohio TechAngels grows to largest angel group in U.S.

Ohio TechAngels may not have been Ohio's first angel fund, but since its founding in 2004 it has grown to become the largest --  not just in Ohio, but in the entire United States.

Earlier this month, Entrepreneur pegged the Columbus-based investment group as the largest in the country with 282 members, ahead of Los Angeles's Tech Coast Angels, with 263 members.

Cleveland-based North Coast Angel Fund also made the top 10 list, coming in fifth with 180 members. Ohio was the only state with two angel groups in Entrepreneur's top 10.

John Huston, who formed Ohio TechAngels in 2004, says there never was a plan to grow the group to any particular size.

"I moved back to Ohio from Boston, where I was a banker, and after a year I was bored," he remembers. "What I missed was working with CEOs."

But when he looked for an angel fund in which to become involved, he could find none in central Ohio, he says. So, to learn how to start his own, he enrolled in a boot camp run by Ohio's first angel fund -- Cincinnati-based Queen City Angels.

Since then, Ohio TechAngels has offered three funds and made 53 investments in 33 Ohio-based, tech-related companies, Huston says.

He says Ohio's angel environment has four things going for it. First is the Ohio Technology Investment Tax Credit, which gives angel investors a 25 percent tax credit for investing in Ohio-based tech startups. Second is the Ohio Third Frontier's Innovation Ohio Loan Fund, which lends money to early stage companies.

"If you're an investor, that's non-dilutive capital, which increases return for shareholders," Huston says. "It provides access to debt before any commercial bank will lend to them. Half of the companies we've invested in have been able to borrow under that program."

A third strength of Ohio's angel environment is what Huston calls "a great infrastructure of incubators" that are equipped to assist early stage companies in ways that help them succeed. And fourth are the pre-seed grants provided by the Third Frontier, he says, noting that a substantial part of Ohio TechAngel's three funds -- some $6 million -- has consisted of state grants that include money from the Third Frontier. 

In the end, Huston says, it's not about how many members Ohio TechAngels has, but how many companies they help.

"The myth is that angels are a bunch of geezers with a lot of money who are trying to make a lot more money," he says. "What we're really trying to do is make meaning -- by building entrepreneurial wealth."

Source: John Huston, Ohio TechAngels
Writer: Gene Monteith


Cincinnati�s Innovative Card Solutions integrates prepaid cards with financial literacy

A Cincinnati-based financial-services company plans to issue prepaid MasterCards to 10,000 college students, thanks largely to an angel investment from William G. Mays (Mays Chemical in Indianapolis) and $250,000 from CincyTech.

Brothers Wyatt and Wade Goins formed Innovative Card Solutions 2008. They now have seven full-time employees. The business offers reloadable debit cards, online financial-literacy courses and money-management tools for businesses and college students.

"Other companies provide prepaid solutions but we integrate financial literacy with our program . . . everything from online money-management tools to financial literacy modules," explains Wade Goins, the company's chief marketing officer.
 
Twenty-three online training modules cover monthly budgeting, credit scores, identity theft and managing college loans. Other money-management tools include mobile messaging alerts.

ICS also helps corporations with direct payroll deposit for employees who don't have bank accounts. For college students, it's a convenient way to manage their money and access tuition refunds.

The company was founded "to teach financial literacy and provide under-served consumers a safe, convenient way of making purchases, paying bills and getting cash," says Goins.

"We use the prepaid card as a tool for behavior modification. We give them the tools they need to manage their money better," he says. "For the last two years we've been developing our technology platform. Now, we're in the launch phase, starting with five universities this fall."
 
The five universities are Urbana University, University of Evansville, Florida Memorial University, Trine University and Wilmington College.

Source: Wade Goins; Chief Marketing Officer, Innovative Card Solutions
Writer: Patrick G. Mahoney


AtriCure continues to grow, snags Third Frontier grant

A $1-million Ohio Third Frontier award will help West Chester-based AtriCure develop and bring to market a next-generation version of its successful AtriClip.

The left atrial appendage is a saclike part of the heart that has internal peaks and valleys. During atrial fibrillation -- an abnormal rhythm of the heart -- the appendage can pool with blood, causing clots that can migrate to the brain and cause strokes.

The Gillinov-Cosgrove Left Atrial Appendage Exclusion system, which the FDA approved  last year for use in open-heart procedures, is designed as a more effective way to close blood flow between the appendage and the atria, thus eliminating the possibility of clots forming there. 

“Today, the clip is approved to be used during the open heart procedure,” says Julie Piton, VP Finance and Chief Financial Officer. The Third Frontier award will help fund development of a minimally invasive version of the device.

AtriCure was formed in 2000 to commercialize and market products developed by Enable Medical Technologies. In August 2005, AtriCure went public and subsequently purchased Enable.

Since then, the company has become a leading medical device company in cardiac surgical ablation systems and systems for the exclusion of the left atrial appendage. Cardiac ablation procedures are used to destroy small areas of the heart that may be cause abnormal heart rhythms.

The company boasted record revenues of $16.8 for the second quarter, with strong growth in international markets. Piton says the company has about 235 employees and has added about 10 in the last year.

Looking ahead, she says the company is poised to become “the first surgical company to get an atrial fibrillation indication” from the FDA.

What that means is that, if approved by the FDA, the company will be able to market its ablation products as a treatment for atrial fibrillation. Currently, they can only be marketed for the ablation of cardiac tissue.

“The only reason you would ablate cardiac tissue is to treat atrial fibrillation,” she says. “But we can’t market our outcomes and we can’t talk to physicians about atrial fibrillation, we can only talk about the technical attributes of our products.”

Source: Julie Piton, AtriCure
Writer: Gene Monteith


ChoreMonster app aims to connect families, make work fun

For most kids there is no getting around chores. Whether it's cleaning their bedrooms, mowing the yard or taking out the trash, they are part of family life.

While the tedious tasks may never make it on the list of things kids look forward to, two Cincinnati entrepreneurs are developing a web-based and mobile application that can make them more enjoyable.

ChoreMonster, now under development, connects chores and rewards through a point system. The application, which can be accessed by parents and their children, gives kids points based on the type of chore they complete. Once they garner enough points, kids can cash them in for real-life rewards like a Christmastime gaming system or $25 for a night out at the movies.

The parent decides how to award points and what rewards to associate with them.

ChoreMonster is the brainchild of Chris Bergman and Paul Armstrong, digital marketing consultants at WiseAcre Digital in Over-The-Rhine.

"I grew up in a household where chores had a negative connotation," says Bergman, whose first child is due in December. "ChoreMonster is a way to enjoy daily chores. We wanted to create an experience where parents could interact with their children in a unique and engaging way. This gives them an opportunity to do that."

ChoreMonster is one of eight startups that are part of The Brandery's 2011 class. The seed stage consumer marketing venture accelerator offers a 12-week course that includes mentoring, 20K in financing upon completion and access to potential investors.

"We already have a lot of strengths (in business) but we want to learn more about strategic partnerships and fundraising. It's a great opportunity to access the network, mentors and the collective wisdom of The Brandeary," says Bergman, of College Hill.

ChoreMonster will be ready for private Beta when The Brandery class finishes this fall, Bergman says. As with each class, the application will be unveiled during a demo day before the public and the local investor community.

Source: Chris Bergman, ChoreMonster
Writer: Feoshia Henderson

You can follow Feoshia on Twitter @feoshiawrites

This story originally appeared in sister publication Soapbox.


BIOSTART moves toward service-based model

Fifteen years after opening its doors, BIOSTART, Cincinnati's life sciences start-up center, is changing the way it does business. In order to remain competitive in a fast-changing business market, it is closing its lab space and moving from its location near the University of Cincinnati.

BIOSTART President Carol Frankenstein says the organization will focus exclusively on business services, making the hard shift as its closes its current facility at the Hoxworth Blood Center in September. She says the change was both a business and a strategic decision.

"Today, companies, even at the very early stages, are outsourcing their commercialization and development activity. That includes clinical and preclinical work, development and manufacturing," Frankenstein says. "That increase in outsourcing reduces the cost of getting a product to market. That makes lab space less necessary. Because of the economy, there is so much low-cost and even free space available; our companies have the ability to benefit from that."

BIOSTART serves life sciences entrepreneurs in health care service and product development. Since 1996, it's helped 125 companies launch their business and raise $180 million. Three-fourths of those businesses have had successful exits or are currently in business, the organization reports.

BIOSTART is working with local business advocates, including the Hamilton County Business Center, Uptown Consortium and CincinnatiUSA Regional Chamber to help its 18 tenant companies (which occupy about 65 percent of its space) to relocate.

Frankenstein said BIOSTART is looking for a new space downtown. She will remain with the organization as will three entrepreneurs in residence. The organization has received $500,000 in funding, half from the Ohio Department of Development and half from private sources, to aid in the transition.

"We're using the grant for the next 12 months to explore new service delivery models," she says.

BIOSTART's current business services include helping companies put together a management team and connecting with and applying for funding sources.

Source: Carol Frankenstein, BIOSTART
Writer: Feoshia Henderson

This story originally appeared in hiVelocity's sister publication, Soapbox.

You can follow Feoshia on Twitter @feoshiawrites

New startups reflect The Brandery's growth, reputation

Cincinnati startup accelerator The Brandery, named a Top 10 startup accelerator in the nation and a member of the TechStars Network, reported a 40 percent increase in applications for its second class of hopeful startups, versus its inaugural class in 2010. This year's applications came from 22 states and seven countries, including India, Germany, China, Italy, Croatia, Canada and Spain.

The 2011 program begins Aug. 1. Over the course of 12 weeks, it will cover a range of startup-related topics such as Why Design Matters for Startups, Social Media Boot Camp and 10 Legal Mistakes that Startups Make. And the nine startups selected to participate in this year's class -- Bitcasa, ChoreMonster, Keepio, Meruni, Receept, RentShare, Roadtrippers and Wellthy -- benefit from not only the programming, but the location of the Cincinnati-based program.

"Cincinnati is not only home to 10 Fortune 500 headquarters, but it's a hotbed for marketing, branding, design and advertising service companies," says The Brandery co-founder J.B. Kropp. "I can't think of a better place for creative, ambitious, young professionals to launch their ideas."

CincyTech is The Brandery's investment partner, providing $20,000 grants for each of the companies going through the program. CincyTech President Bob Coy says The Brandery is helping CincyTech meet its goal of growing jobs in the region.

"The Brandery has demonstrated its ability to attract talented entrepreneurs from around the country and the world to Cincinnati to capitalize on the region's consumer marketing strengths," says Coy. "Our hope is that they will become embedded in the community and enrich the region's entrepreneurial talent base. And of course that means they will help to invigorate our economy by creating jobs and wealth and bringing new perspectives from other regions of the U.S. and the world."

Sources: J.B. Kropp, The Brandery; Bob Coy, CincyTech
Writer: Sarah Blazak for CincyTech

This story originally appeared in sister publication Soapbox.

Local mother launches Grateful Grahams all natural, vegan snacks

After a career in marketing, Linwood mother Rachel DesRochers decided to stay home full-time after having her second child. Soon, she got the itch to work and create.

"I needed something to do," she says. "When you finally don't have a job, you get bored. You can only clean the house so much."

DesRochers turned to baking last year, specifically graham cookies and snacks. She started sharing them with friends and family and her tasty treats were a hit. That's when she decided to sell them.

"People loved them. So I thought, 'I'm going to do it," she says.

She unveiled Grateful Grahams, home-made, vegan graham snacks, at this year's Earth Day event at Sawyer Point. She developed and perfected the recipes for the snacks. The soft, square snacks currently come in two flavors, cinnamon and sugar, and chocolate. Snack packs retail for $4 and large bags for $6.

"I did research on grahams. I started playing around with ingredients and made a recipe that worked. It was important to me to use simple, green ingredients," she says.

You can find Grateful Grahams at a number of local stores including Picnic and Pantry, Park +Vine, and Joseph Beth and Blue Manatee bookstores. You can also find them at local Whole Foods stores.

DesRochers plans to expand her offerings with a pie crust and a line of holiday flavors.

She bakes in a commercial kitchen that she shares with a local bakery. She recently had a third child, and Grateful Grahams allows her to do something she loves and spend time with her family, she says. Like her grahams, she is grateful.

"I don't want to work 80 hours a week. I want to be a mom, and show my kids that I have something I love do to. It can be hard juggling a family and a business, but I have a network that supports me and really that's from where the company is driven," she says.

Source: Rachel DesRochers, Grateful Grahams
Writer: Feoshia Henderson

You can follow Feoshia on Twitter @feoshiawrites

This story originally appeared in hiVelocity's sister publication Soapbox.

UC researcher earns NIH grant for miRNA study

A University of Cincinnati neurobiologist may soon help mental health researchers understand depression at a more effective level than ever before, thanks to an innovative research method and a nearly-quarter-million-dollar grant from the National Institutes of Health.

James Herman, PhD, received a two-year NIH grant worth $248,159 in its first year to fund research into the role that microRNA (miRNA) - molecular-level controllers that help regulate the brain's chemistry -- play in how the brain reacts to stress.

"We're attempting to develop this as a discovery platform to understand what's going on in the brain," Herman says. He explains that this research, in which scientists analyze how miRNA in mice affect the brain's mood-regulating prefrontal cortex, is very early-stage work in the exploration of the molecular process behind depression.

But the ultimate implications of Herman's work could be significant. He explained that miRNA in mice function the same as miRNA in humans: identify a link between mouse miRNA and a brain dysfunction, and there's good reason to look for a similar relationship in the human brain. Beyond this tantalizing fact, though, scientists don't completely understand how miRNA works, or even how many types of miRNA exist in the brain.

Herman's team is tackling this hurdle with a new analysis technique, called deep sequencing, to analyze miRNA at a high level of detail.

"The method is really, really powerful," he says. Processing one set of data from a sample, for example, can keep lab computers running nonstop for a weekend. Thanks to a collaboration with informatics researchers at the University of Michigan, Herman's team can spot relationships and patterns in this sea of data, results that could help scientists link certain miRNA function -- or dysfunction -- to the stress-processing problems underlying depression and mood disorders.

These results could eventually give psychiatrists a new weapon against mood disorders. Rather than giving a patient medicine that floods the brain with mood-altering chemicals - a practice that often comes with severe side effects - physicians could one day provide treatment that fixes the way the brain controls its own chemistry. Medicine has a long way to go to reach that point, but the work Herman's team is undertaking at UC could be a major step in the right direction.

Source: James Herman, University of Cincinnati
Writer: Matt Cunningham

This story originally appeared in hiVelocity's sister publication, Soapbox.

Airway Therapeutics developing remedy for lung disease in preemies

A new Cincinnati company is hoping to give premature babies a better chance of growing healthy lungs.

Airway Therapeutics, formed earlier this month, is working to commercialize research begun at Cincinnati Children's Hospital Medical Center into why so many premature babies develop chronic lung disease.

Extremely premature babies -- those born before the seventh month of gestation -- come into the world without surfactant, a natural substance found in animal lungs that keeps the lungs inflated. The remedy is to replace the baby's natural surfactant with one made from animal lung tissue, says Steven Linberg, Airway's CEO.

"But part of the process of giving them the surfactant involves either mechanically ventilating the baby or hand bagging the baby just to force some air into their lungs, and also giving them higher than normal amounts of oxygen," Linberg says.

That often causes trauma and chronic lung disease for as many as 30 percent to 40 percent of such babies. Now, research by Jeffrey Whitsett, chief of Cincinnati Children's Section of Neonatology, Perinatal and Pulmonary Biology, indicates inflammation may be worsened because of a lack of Surfactant Protein D, which occurs in normal surfactant but is missing in replacement surfactant. Airway is working on a recombinant human Surfactant Protein D with the goal of adding it to replacement surfactant as nature intended. If shown to reduce or prevent chronic lung disease in preemies, all makers of surfactant would like add the protein to their products, Linberg says.

The next step for Airway is to meet with the U.S. Food and Drug Administration, possibly in August, for validation of its development plan, Linberg says. Because of the number of both non-clinical and clinical studies to be done, the earliest Linberg expects to see Surfactant Protein D on the market is 2016.

"Our next goal beyond this is to move into cystic fibrosis," Linberg says. "It's likely that because this Surfactant Protein D is both anti-inflammatory and anti-infective, it will have a positive role in treating cystic fibrosis patients."

The company currently has a number of consultants but only one employee -- Linberg. It is housed at BioStart and recently received $500,000 from CincyTech and Cincinnati Children's Tomorrow Fund as part of a projected $1.2-million seed-stage funding round led by CincyTech.

Source: Steven Linberg, Airway Therapeutics
Writer: Gene Monteith
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